FOLIC ACID
General Description:
- folate is another name for folic acid
- folate is a water soluble vitamin
Actions:
- folate is absolutely essential for healthy bones, for a healthy pregnancy, and for the
metabolism of proteins, as it forms part of the vital transport coenzymes that control
amino acid metabolism
- necessary for the growth and division of all cells in the body and for the production
of RNA and DNA, the nucleic acids that carry hereditary patterns
- folate helps to prevent breakage of DNA which is probably a key step in the cancer process
- folate may be able to turn precancerous conditions of the lung and cervix around
- essential for the formation of RBCs
- folic acid must be present in adequate amounts for iron to initiate hemoglobin synthesis
- aids in protein metabolism and contributes to normal growth
- essential for the healing process
- helps build antibodies to prevent and heal infections
- essential for the health of hair and skin
- helps prevent premature graying of hair
- long been used in the treatment of atherosclerosis, circulation problems, anemia, radiation
injuries and burns, in the treatment of sprue, a tropical nutritional disease, anemia and
acute diarrhea
Deficiency:
- RDA is 200 mcg.
- a deficiency of folic acid inhibits the growth of new cells, especially the rapidly
dividing ones (eg. blood and muscle cells)
- a deficiency of folic acid can cause a type of anemia (megaloblastic), with early symptoms
of fatigue, loss of appetite, pallor, and inflammation of the tongue, a tell-tale sign.
- other symptoms include: serious skin disorders, loss of hair, impaired circulation,
a grayish-brown skin pigmentation, depression, reproductive disorders (spontaneous abortions,
difficult labor, and high infant death rate), and loss of libido in males
- most frequently the victims of folate deficiency are alcoholics, those suffering form
malabsorption syndromes, and the elderly
- folate can mask the signs of pernicious anemia, caused by vitamin B12 deficiency and
B12 deficiency, although quite rare, can lead to irreversible nerve damage if left unchecked
- folate needs increase during pregnancy
- alcohol causes the body to excrete more folate than normal
- many drugs interfere with folic acid nutrition: antibacterial, anticancer, anticonvulsant,
antituberculosis, barbiturates, birth control pills, cortisone, sulfa drugs etc.
Interactions and Toxicity:
- large doses of folate can mask the symptoms of pernicious anemia, a disorder marked
by an inablity to absorb vitamin B12.
- toxicity is low, but the FDA has restricted the dose to 400 mcg./day, because of its
possibility of masking signs of pernicious anemia
- high doses may interfere with your body's abliity to absorb and retain zinc
- increased zinc has been found in the blood in cases of folic acid deficiency
Sources:
- dark-green leafy vegetables, legumes, asparagus, lima beans, Irish potatoes, brewer's
yeast, wheat germ, mushrooms, nuts, and egg yolk